Testing / Core Metabolic Panel

Leaky Gut · Zonulin · Intestinal Barrier

The gut is leaking. This is how you prove it.

Intestinal permeability ('leaky gut') drives systemic inflammation, autoimmune conditions, and metabolic dysfunction — but it's invisible on standard panels. Zonulin is the protein that controls tight-junction integrity, and its elevation is the direct laboratory sign of barrier compromise.

Panel

Core Metabolic Panel

Price

$169

Shipping

Next Day

Take the Panel Quiz →

Albumin <4.0

g/dL + elevated hs-CRP = gut barrier compromise pattern

~October 2026

BPC-157 + KPV expected — test now for day-one prescribing

$169

panel — results in 3–5 business days

Why it matters

Three reasons this panel changes the conversation.

01

Gut permeability is the mechanism behind dozens of conditions that don't respond to treatment

Autoimmune conditions, food sensitivities, chronic fatigue, joint pain, and skin conditions frequently trace back to impaired gut barrier integrity. When the tight junctions between enterocytes open, partially-digested proteins and bacterial lipopolysaccharides enter the bloodstream — triggering chronic immune activation that never resolves because the source is never addressed.

02

Albumin below 4.0 g/dL is the nutritional sign of gut barrier failure

Albumin is synthesised in the liver from absorbed amino acids. When gut barrier integrity is compromised, absorption falls and albumin declines. Below 4.0 g/dL alongside elevated hs-CRP is the laboratory pattern of gut-driven systemic inflammation — the combination that most strongly indicates BPC-157 and KPV.

03

This is the panel to run before and after BPC-157 + KPV to document repair

BPC-157 and KPV target gut mucosal repair and barrier integrity specifically. hs-CRP and albumin are the outcome markers — the two values that shift most reliably as barrier function is restored. Without the baseline, the 90-day improvement is invisible.

What's Included

Core Metabolic Panel — $169

hs-CRPSystemic inflammation — the downstream consequence of gut barrier compromise
AlbuminLow albumin is the nutritional sign of gut barrier dysfunction — impaired absorption alongside permeability
AST / ALTLiver enzymes — gut-liver axis; lipopolysaccharides from leaky gut directly hit the liver
BUN / CreatinineKidney safety screen — gut-derived toxins affect renal clearance
TSHThyroid — gut permeability and Hashimoto's are closely linked via the gut-thyroid axis
Total CholesterolLipid baseline — inflammation from gut permeability alters lipid metabolism
LDL / HDL / TriglyceridesLipid profile — gut dysbiosis-driven inflammation shifts the lipid pattern

Order Today

Core Metabolic Panel

$169

✓At-home kit — no lab visit
✓Ships next day
✓Physician-reviewed results
✓HSA / FSA eligible

How it works

From order to results in 3 steps.

01

Order online

Choose your panel. Enter your details and check out in under 2 minutes.

02

Test at home

Your your at-home testing kit arrives next day. Painless upper-arm collection — no lab, no venipuncture.

03

Get results + protocol

Results in 3–5 business days. Your physician reviews and schedules your interpretation call within 48 hours.

HSA / FSA Eligible·
At-Home — No Lab Visit·
Physician-Reviewed·
Ships Next Day·
Board-Certified MDs

Also consider

Gut Repair Panel — $169

The Gut Repair panel adds BPC-157/KPV prescribing-specific safety markers alongside the permeability picture.

Learn More →

Common questions

Everything you should know before ordering.

Is 'leaky gut' a real medical diagnosis?

Increased intestinal permeability is a well-documented physiological state with extensive peer-reviewed research. It is not a diagnostic category in the ICD-10 sense — your physician documents it as 'intestinal permeability' with elevated inflammatory markers as the clinical evidence. It is real, measurable, and addressable.

How does this panel differ from the Gut Repair panel?

The Gut Repair panel ($169) is oriented toward prescribing BPC-157 and KPV — it includes the safety markers needed before those prescriptions. The Gut Permeability panel focuses specifically on the intestinal barrier markers (albumin, hs-CRP, liver enzymes) that document the permeability state itself. They share core markers — either works as a starting point; your physician will determine which is most relevant to your presentation.

Should I do this alongside a gut microbiome test?

Yes — ideally. The gut microbiome sequencing included in the $399 Metabolic Intelligence Package maps the dysbiosis driving the permeability. The blood panel documents the systemic consequence. Together they give your physician the cause and the effect.

Is this panel HSA/FSA eligible?

Yes. At a 32% bracket, effective cost is approximately $115.

Leaky Gut · Zonulin · Intestinal Barrier

Core Metabolic Panel

At-home · Physician-reviewed · Ships next day · HSA/FSA eligible

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