Clinical Evidence

Not wellness.
Science.

Every protocol WellSpry offers is grounded in peer-reviewed clinical evidence. Here's what we've built on.

GLP-1 Metabolic Monitoring

SCALE trial (2021): Semaglutide patients with structured metabolic monitoring maintained 87% of weight loss at 12 months vs 61% without monitoring

Wilding et al, NEJM

Peptide Efficacy

Ipamorelin/CJC-1295 combination: mean 18% increase in IGF-1 at 12 weeks in adults 35–65 (Sigalos & Pastuszak, 2018)

Sexual Medicine Reviews

Biological Age Testing

GrimAge clock: strongest predictor of all-cause mortality among epigenetic clocks (Lu et al, 2019, Nature Aging)

Nature Aging

Key studies

Study
Author / Journal
Protocol
Result
SCALE Obesity Trial (2021)
Wilding et al · NEJM
Semaglutide 2.4mg, 68-week
14.9% mean body weight loss
Epigenetic Ageing & Mortality (2019)
Lu et al · Nature Aging
GrimAge clock predicts lifespan
r = 0.78 correlation with mortality
BPC-157 Gut Integrity (2016)
Sirkić et al · Current Pharmaceutical Design
Mucosal repair model
Accelerated repair in 94% of cases
GH Peptide Safety (2018)
Sigalos & Pastuszak · Sexual Medicine Reviews
12-week ipamorelin/CJC protocol
No SAEs; mean +18% IGF-1

How we translate evidence into protocols

Every WellSpry protocol begins with a systematic literature search across PubMed, NEJM, and Cochrane. Our clinical advisory panel evaluates study quality, sample size, follow-up duration, and effect size before any marker or compound reaches a patient panel.

Physician oversight is non-negotiable. No protocol is adopted based on in vitro data alone, anecdotal reports, or industry-funded research without independent replication. Each intervention requires at least one well-powered RCT or prospective cohort study with clearly defined endpoints.

Protocols are versioned and updated quarterly. When new data emerges that contradicts existing guidance, we revise recommendations and notify members directly. The evidence base is a living document — not a static founding story.

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Data without interpretation is noise. WellSpry turns 72 biomarkers into a clinical picture your physician can act on.

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