Testing10 min readMarch 2026

What to test before GLP-1 therapy: educational lab context

Baseline testing needs vary by patient, medication, and clinician judgment. Here are 10 biomarker categories that may inform treatment discussions, provide background for longitudinal comparison, or require separate outside testing. They do not predict side effects or establish treatment eligibility, safety, or efficacy.

Published by WellSpry Editorial Team · Pending independent physician review · Review status →
Key Takeaways
→Testing needs differ by patient, medicine, history, and current clinical guidance
→A blood panel does not assess every warning or contraindication
→No catalog marker predicts an individual's GLP-1 response or selects a medication
→Abnormal results require clinical interpretation and may need confirmatory testing
→Values outside the exact catalog listing require separate testing if an independent clinician needs them

Baseline laboratory data may help an independent clinician understand prior values or compare later results, but there is no universal ten-test minimum. History, examination, medicines, and treatment-specific guidance may be as important as laboratory findings.

This is an educational testing framework, not the composition of a WellSpry kit. WellSpry's widest at-home panel returns 18 catalog-listed markers. Fasting insulin, HOMA-IR, and other values below that are not in the catalog, require separate outside testing, and should be discussed with your own licensed clinician.

01

TSH + fT3 + fT4

Thyroid context

Medication warnings and contraindications require a review of personal and family history by the treating clinician; thyroid laboratory values do not replace that review. Free T3 and T4 require separate outside testing if an independent clinician needs them, and no result establishes treatment eligibility or safety.

02

Fasting glucose + HbA1c

Glycemic baseline

Fasting glucose and HbA1c provide different views of glucose regulation and may be useful for longitudinal context. Diagnosis, medication selection, and monitoring decisions require independent clinical evaluation rather than a panel result alone.

03

Fasting insulin + HOMA-IR

Insulin resistance measurement

HOMA-IR is a research and clinical estimate calculated from fasting insulin and fasting glucose. Interpretation varies by method and patient context; it does not predict an individual's weight-loss response or establish a nutrition, exercise, or medication plan. WellSpry does not return fasting insulin or calculate HOMA-IR.

04

AST + ALT + GGT

Liver function baseline

Liver enzymes can provide clinical context but do not diagnose hepatic steatosis by themselves. Abnormal results may have many causes and require interpretation by a licensed clinician; they do not establish treatment eligibility, safety, or expected benefit.

05

BUN + creatinine + eGFR

Kidney function

Kidney markers can provide clinical context, especially when illness, dehydration, or other medicines are relevant. A result does not independently determine medication safety or dosing. BUN is not returned by a WellSpry panel; the treating clinician decides what testing and follow-up are needed.

06

Total testosterone + free testosterone

Hormonal baseline

Testosterone results require sex-specific ranges, symptoms, timing, and other clinical context. They do not predict GLP-1 response, determine lean-mass change, or justify a hormone, peptide, or other treatment. Free testosterone is not returned by a WellSpry panel.

07

DHEA-S + cortisol (AM)

Adrenal hormone baseline

DHEA-S and cortisol may be relevant to specific clinical questions, but results vary with age, timing, stress, sleep, illness, and medicines. Neither is returned by a WellSpry panel, and neither establishes GLP-1 eligibility or predicts response.

08

hsCRP + homocysteine

Inflammatory and cardiovascular markers

Inflammatory and cardiovascular markers require laboratory-specific and clinical interpretation. They do not establish treatment candidacy or predict an individual benefit. The catalog names an Inflammation output but does not identify it as hsCRP; homocysteine requires separate outside testing.

09

Full lipid panel (TC, LDL, HDL, TG) + LDL-P

Cardiovascular baseline

A lipid panel can provide cardiovascular context and a point for later comparison. LDL-P uses a different measurement approach and is not returned by a WellSpry panel. Lipid values do not select between medicines or predict an individual response.

10

Vitamin D3 + B12

Deficiency screening

Vitamin testing may be appropriate when diet, symptoms, medicines, or medical history support it. Results do not predict GLP-1 side effects or prove that supplementation will improve treatment. Vitamin B12 is not returned by a WellSpry panel.

What to do if labs are abnormal

Do not use this article or a single result to diagnose a condition or change treatment. Unexpected values may need repeat or confirmatory testing, review of medicines and symptoms, or referral. The patient's own licensed clinician determines the next step; WellSpry does not decide whether a person should start, change, or stop medication.

The WellSpry baseline panel

WellSpry's most comprehensive at-home panel returns 18 catalog-listed markers. It does not cover every category above. Any recommended value outside the catalog requires separate outside testing and should be brought to your own clinician. Choose Health handles account activation, consent, lab processing, clinician review, result-ready notification, and secure portal delivery.

Review the available metabolic panel.

18 catalog-listed markers. The panel is not treatment clearance. Choose Health handles account activation, consent, lab processing, clinician review, and secure portal delivery.

Review panel details →

Frequently Asked Questions

Can I start GLP-1 therapy without getting labs first?

Only your own licensed clinician can decide which evaluation and testing are appropriate before treatment. Requirements vary by patient, medicine, history, and current guidance. A WellSpry panel is not treatment clearance and does not assess every contraindication or warning.

How long before starting GLP-1 should I get labs?

There is no universal timing rule. A licensed clinician can decide whether prior results remain relevant or whether repeat testing is needed based on health changes, current medicines, and the treatment being considered.

Does insurance cover pre-GLP-1 labs?

Insurance coverage and HSA/FSA reimbursement depend on the plan and applicable expense rules. WellSpry's at-home panel is available as a separate purchase; confirm coverage or reimbursement eligibility with your insurer or plan administrator.